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What is the expression profile of a particular gene? | GUDMAP
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What is the expression profile of a particular gene?

You can use GUDMAP to find the gene expression profile of a gene. On this page, we’ll answer the following question:

What is the gene expression profile of Slc22a3 (solute carrier family 22) in the developing reproductive system of the mouse?

On this page:

Step 1: Search by gene

On the home page of www.gudmap.org, use the search box, making sure the “GENE” radio button is selected, and enter the desired NCBI gene symbol, in this case “Slc22a3”.

If you’re not sure of the NCBI gene symbol, we also include most common synonyms in our gene search.

screenshot of gene search on homepage

Or go to BROWSE DATA > Gene in the menu bar at the top of any page and enter “Slc22a3”

In the results, you’ll see various options for “Slc22a3” - including gene symbols that contain the string “Slc22a3” (e.g., Slc22a30).

screenshot of searching by gene in Chaise

To narrow your results, use the filtering sidebar. Below you’ll see what happens when you filter by Species.

screenshot of searching by gene in Chaise

Step 2: See if array data is available for that gene

In the “Slc22a3” row, when you look in the “Available Expression Data” column, you will see that there is array data available.

Click the “View” icon for that row to go to the Gene page for Slc22a3.

screenshot of where Array Data is appears if available

The following is a screenshot of the “Slc22a3” gene record page:

screenshot of the Slc22a3 gene record page

Step 3: Review the heatmaps in the “Array Data” section on the Gene page

On the gene record page, scroll down to the “Array Data” section and you’ll see several heatmaps available by region.

screenshot of the Array Data section

We recommend clicking the “Microarray Data (full screen)” to view the heatmaps at full size.

screenshot of the array data in full screen mode

Look for the heatmap titled “Reproductive Gonadal”, then hover over the bars to see the titles which describe the tissue sample by age stage and region (which are also available in the verticle lines of text below each rectangle).

  • Red indicates more expression.
  • Blue indicates less expression.

screenshot of the what it looks like when you hover over the heatmaps