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GUDMAP2 Projects | GenitoUrinary Development Molecular Anatomy Project (GUDMAP)
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GUDMAP2 Projects


Cohn Group

Congenital malformations of the external genitalia are among the most common birth defects in humans. Hypospadias is a structural defect of the penis that is characterized by incomplete formation of the urethral tube and associated stromal tissues. Affected children can have oversized, ectopic or multiple urethral openings and, in severe cases, ambiguous genitalia. All but the mildest forms require surgical intervention. The incidence of hypospadias more than doubled over the past 40 years and now affects ~1 of every 250 live births. Despite the magnitude of this public health problem, little is known about the molecular mechanisms of urethral or external genital development... more

Edinburgh Core Database Group

PIs: Richard Baldock & Jamie Davies
The central hub of the GUDMAP project is a database and its associated website. The Core Database group is responsible for design, construction, maintenance and development of the database, its interfaces and associated website information. It is also responsible for curation and editing of data and for assisting submitters and users of GUDMAP's resources. The Core Database group, working with Melissa Little’s lab, continues to extend the standard ontology by which the genituourinary system is described. The Little lab also helps to provide the expertise to improve the accessibility and utility of the database. Bruce Aronow and his group provide bioinformatics expertise, undertake the primary analysis of array data and deliver the interoperability with ToppGene for functional analysis... more

Keast Group

The primary functions of the mature lower urinary tract – storage and voiding – depend on a healthy central and peripheral nervous system. In the immature postnatal system, voiding is “automatic”, i.e., controlled by spinal and local processes. However, during further maturation there is a dramatic transition in regulatory mechanisms, such that in the healthy adult, filling triggers a conscious need to void but micturition is determined voluntarily by the brain to occur at an appropriate time and place. Around puberty, further changes coordinate bladder, bowel and sexual activity. Numerous changes occur in the nervous system over these periods, although the cellular loci and molecular mechanisms have not been well defined... more

McMahon Group

Genetically-modified mouse strains play an important role in unraveling tissue organization and modeling disease processes. In GUDMAP1, the McMahon group created and characterized a number of novel mouse strains to facilitate identification, isolation and genetic manipulation of key cell types within the genitourinary system. Strains are available through the Jackson Laboratories and details of the strains and their activities can be seen at the GUDMAP website more

Mendelsohn Group

The urinary outflow tract, including the renal pelvis, ureters, bladder and upper urethra, is lined by a specialized stratified epithelium called the urothelium, composed of a basal layer, an intermediate layer and a superficial layer consisting of umbrella cells. Umbrella cells are large multinucleated cells that are specialized for synthesis and trafficking of Uroplakins, a family of secreted proteins that assemble into the crystallin plaque lining the apical surface of the urothelium that generates a leak-proof barrier between the urine and the blood… more