GUDMAP - For Biologists
Given the importance of the genitourinary system for human health and reproduction, the need for a systematic molecular and cellular description of its developmental program is clearly a high priority. In late 2004, the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) and the National Institute of Child Health and Human Development (NICHD) established an International Consortium of research groups charged with the task of producing a high quality molecular anatomy of the developing mammalian urogenital tract. The information obtained through this initiative is anticipated to enable the highest level of basic and clinical research grounded on a 21st century view of the developing anatomy.
There are three components to GUDMAP, all intended to provide resources that support research on the kidney and urogenital tract.
1) a description of genitourinary development that includes a tutorial, an ontology of anatomical parts and the molecular hallmarks of those structures.
2) novel mouse strains in which tissues of particular interest are marked and can be genetically manipulated.
3) a public database that reports the gene expression data arising from the project as soon as it becomes available (determined by in situ hybridization, immuno-staining, microarrays).
The primary entry point for developmental biologists is the GUDMAP gene expression database page. From here the user can query, browse and download the data held in the database.
- GUDMAP Demos
- Flash slideshows that illustrate how to use the GUDMAP website and database to answer biological questions. Please follow the links here:
- Demo 1: How do I find where my gene of interest is expressed during GU development?
- Demo 2: What genes specifically mark the structure I am interested in examining?
- Demo 3: What genes, within a genetic interval, are likely to have disease-causing mutations?
- Demo 4: How does the GU tract develop?
- GUDMAP orientation movies
- Voice-over movies are designed to help familarise users with navigating the GUDMAP website. Please follow the links here:
- movie 1: introduction to GUDMAP - basic description of the GUDMAP gene expression page.
- movie 2: browsing microarray data - more detail description of using GUDMAP to browse microarray data (recommended).
- please note: due to the continuous development of the website pages in the movies, whilst similar, will not be entirely representative of the current pages on the website.