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Summary of mouse strains characterised by GUDMAP consortium

Mouse strains generated by GUDMAP consortium

Sort ID GUDMAP ID Gene Reporter Allele Allele Type Allele Verification Allele Characterisation Strain availability Organ* Cell Type*
1 21856 Id3 Id3-RFP ES cell derived download (Zhang Lab) download (McMahon Lab) Jax strain 010983 Kidney Broad expression including ureteric tree terminal branch excluding tip itself, renal cortical interstitium and renal capsule
2 21859 Upk1b Upk1b-RFP ES cell derived download (Zhang Lab) download (McMahon Lab) Jax strain 010984 Lower urinary tract Urothelium of ureter and bladder
3 21860 Klf3 Klf3-GFP-Cre-ERT2 ES cell derived download (Zhang Lab) download (McMahon Lab) Jax strain 010985 Kidney, reproductive system Collecting duct, renal interstitium. Testis, ovary.
4 21862 Osr2 Osr2-RFP ES cell derived download (Zhang Lab) download (McMahon Lab) Jax strain 010986 Kidney, male reproductive system Cortical renal tubule, highest in proximal segment of s-shaped body. Genital ducts and testis.
5 21863 Sox18 Sox18-GFP-Cre-ERT2 ES cell derived download (Zhang Lab) download (McMahon Lab) Jax strain 010987 Vasculature Renal cortical and medullary vasculature
6 21869 Cyp11a1 Cyp11a1-GFP-Cre ES cell derived download (Zhang Lab) download (McMahon Lab) Jax strain 010988 Male reproductive system Leydig cell (and adrenal gland)
7 21881 Ifitm3 (Fragilis) Ifitm3-RFP ES cell derived download (Zhang Lab) download (McMahon Lab) Jax strain 013139 Reproductive system Reproductive system - germ cell
8 21886 Akr1b7 Akr1b7-TagRFP-T BAC transgenic download (McMahon Lab) download (McMahon Lab) Jax strain 013137 Kidney Medullary vasculature
9 21887 Upk3a Upk3a-GFP-Cre-ERT2 BAC transgenic download (McMahon Lab) download (McMahon Lab)

Jax strain 015855

Lower urinary tract Urothelium of ureter and bladder
10 21889 Tmem100 Tmem100-GFP-Cre-ERT2 BAC transgenic download (McMahon Lab) download (McMahon Lab) Jax strain 014159 Kidney, reproductive system, vasculature Proximal renal vesicle, parietal epithelium adjacent to WT1+ve cells demarcating future podocytes of Bowmanʼs capsule. Renal cortical vasculature. Wolffian and Mullerian ducts.
11 21878 S100b S100b-GFP-Cre-ERT2 BAC transgenic download (McMahon Lab) download (McMahon Lab) Jax strain 014160 Glial lower urinary tract Pelvic ganglia, glial progenitors in bladder. Developing bone.
12 21891 Uchl1 Uchl1-mCherry/GFPgpi BAC transgenic download (Southard-Smith Lab) download (Southard-Smith Lab) Jax strain 016981 Urinary system, reproductive system Autonomic nervous system
13 21892 Foxl2 Foxl2-GFP-Cre-ERT2 ES cell derived download (Zhang Lab) download (McMahon Lab) Jax strain 015854 Female reproductive system Ovary medulla, granulosa cell precursors
14 21893 Cited1 Cited1-TagRFP-T BAC transgenic download (McMahon Lab) download (McMahon Lab) Jax strain 015853 Kidney, male reproductive system Cap mesenchyme (reproductive system expression not characterised)
15 21895 Tshz3 Tshz3-GC BAC transgenic download (McMahon Lab) download (McMahon Lab) Jax strain 017494 Kidney Smooth muscle actin positive cells (some ectopic expression and some non-expressing domains in urogenital system)
16 21896 Crim1 Crim1-GCE ES cell derived download (Zhang Lab) download (McMahon Lab) Jax strain 017495 Vasculature Endothelial cells (subset of PDGFR-b population)
17 21897 Lfng Lfng-nucTagRFP-T-IRES-CE BAC transgenic download (McMahon Lab) download (McMahon Lab) Jax strain 017496 Kidney Renal vesicle, early tubule
18 21898 Wnt11 Wnt11-myrTagRFP-T-IRES-CE BAC transgenic download(McMahon Lab) download (McMahon Lab) Jax strain 018683 Kidney Ureteric bud, ureteric tip, ureteric tree, developing collecting ducts, mesonephros of male and mesonephros of female
19 21899 Meox Meox1-nuc TagRFP-T-IRES-CE BAC transgenic download(McMahon Lab) download (McMahon Lab) Jax strain 018682 Kidney Cap mesenchyme progenitors, renal vesicle derivatives
20 21879 Spp2 Spp2 G2aCE ES cell derived (dRMCE)   download(McMahon Lab) Jax strain 025209 Kidney Proximal tubule
21 21880 Entpd5 Entpd5 G2aCE ES cell derived (dRMCE)   download(McMahon Lab) Jax strain 025208 Kidney Proximal tubule
22 22100 Wnt10b Wnt10b G2aCE ES cell derived (dRMCE)   download(McMahon Lab) Jax strain 028116 Male reproductive, lower urinary tract, skin prostate cells (keratin-5 population), epididymis, bladder, skin
23 22311 Srd5a2 Srd5a2-F2aeGFPT2aCE ES cell derived (dRMCE)   download(McMahon Lab) Jax strain 028117 Male reproductive system prostate cells, seminal vesicles, other male reproductive tract
24 23264 Krt20 Krt20-T2A-CRE-ERT2 ES cell derived (dRMCE)   download(McMahon Lab)   Bladder, intestine epithelial cells of intestine, superficial Uroplakin III+ component of the bladder epithelial umbrella cell population
25 23265 Slc12a3 Slc12a3-IRES-CRE-ERT2 ES cell derived (dRMCE)   download(McMahon Lab)   Kidney distal tubule segment of the nephron
26 23266 Trpv4 Trpv4-CRE-ERT2 ES cell derived (dRMCE)   download(McMahon Lab)   Skin epidermis, rib cartilage epithelial of skin,chondrocyte cells of the rib
27 23270 Umod Umod-IRES-CRE-ERT2 ES cell derived (dRMCE)   download(McMahon Lab)   Kidney Loop of Henle
28 23271 Gfra3 Gfra3-CRE-ERT2 ES cell derived (dRMCE)   download(McMahon Lab)   Bladder glial cells

* Please note that whilst expression has been analysed in other parts of the urogenital system this analysis has not been exhaustive so that other sites of expression may exist.


Mouse strains generated by external sources

Sort ID GUDMAP ID Gene Reporter Allele/Transgenic Allele Type Allele Characterisation Strain acquired from Organ* Cell Type*
1 22103 Hes5 Hes5-GFP BAC transgenic download PDF / download movie (.avi) (Potter Lab) MMRRC Kidney Medial segment of s-shaped body (TS23)
2 22106 MafB MafB-EGFP BAC transgenic download PDF (Potter Lab) MMRRC Kidney Visceral epithelium of glomerular tuft, synonym: podocyte layer (TS23)
3 22107 Nrp2 NRP2-EGFP BAC transgenic download PDF / download movie (.mov) (Potter Lab) MMRRC Kidney Early proximal tubule, renal cortical interstitium (TS23)
4 22108 Sim1 Sim1-EGFP BAC transgenic download PDF / download movie (.mov) (Potter Lab) MMRRC Kidney Ureteric tip, ureteric tree terminal branch, cortical collecting duct, renal connecting tubule and early distal tubule (TS23)
5 22113 Notch2 Notch2-EGFP BAC transgenic download PDF / download movie (.mov) (Potter Lab) MMRRC Kidney Maturing renal corpuscle, s-shaped body, early proximal tubule and cortical collecting duct (TS23)
6 22110 Irx3 Irx3-EGFP BAC transgenic download PDF / download movie (.mov) (Potter Lab) MMRRC Kidney Renal interstitium (TS28, adult)
7 22114 Meis1 Meis1-EGFP BAC transgenic download PDF / download movie (.avi) (Potter Lab) MMRRC Kidney Renal cortical and medullary interstitium (TS23); glomerula and extraglomerula mesangium (TS28, adult)
8 22115 Sema3b Sema3b-EGFP BAC transgenic download PDF / download movie (.avi) (Potter Lab) MMRRC Kidney Collecting duct, early tubule, late tubule (TS23)
9 22105 Crym Crym-EGFP BAC transgenic download PDF / download movie (.mov) (Potter Lab) MMRRC Kidney Cap mesenchyme (TS23)
10 22130 Htr3a Htr3a-EGFP BAC transgenic download PDF (Southard-Smith lab) MMRRC Periphral nevous system, lower urinary tract Dorsal root ganglia, pelvic ganglia, genital tubercle
11 22131 Th Th-EGFP BAC transgenic download PDF (Southard-Smith lab) MMRRC Periphral nevous system, lower urinary tract Celiac ganglia, pelvic ganglia, adrenal
12 22907 Ret Ret-floxEGFP ES cell derived conditional reporter allele download PDF (Jain Lab)   Urinary system, peripheral nervous system nephric duct, ureteric bud and tips, sympathetic, parasympathetic, enteric, sensory and motor neurons
13 22908 Ret Ret-EGFP ES cell derived reporter allele download PDF (Jain Lab)   Urinary system, peripheral nervous system nephric duct, ureteric bud and tips, sympathetic, parasympathetic, enteric, sensory and motor neurons

* Please note that whilst expression has been analysed in other parts of the urogenital system this analysis has not been exhaustive so that other sites of expression may exist.


Summary of cell lines characterised by members of the GUDMAP consortium

Urogenital system cell lines funded by external sources

Sort ID Designation Contributor / Lab Source Organism / Strain Source Tissue Cell Type Cell Line Requests Cell Line Data Sheet (Davies Lab)
1 6TA1 G Tai / Davies Lab Mus musculus / H-2Kb-tsA58 ‘Immortomouse’ metanephros (11.5dpc embryonic kidney) ureteric bud Jamie Davies download
2 6TA2 G Tai / Davies Lab Mus musculus / H-2Kb-tsA58 ‘Immortomouse’ metanephros (11.5dpc embryonic kidney) ureteric bud Jamie Davies download
3 6TA3 G Tai / Davies Lab Mus musculus / H-2Kb-tsA58 ‘Immortomouse’ metanephros (11.5dpc embryonic kidney) ureteric bud Jamie Davies download
4 C1A1FF G Tai / Davies Lab Mus musculus / H-2Kb-tsA58 ‘Immortomouse’ metanephros (11.5dpc embryonic kidney) metanephric mesenchyme Jamie Davies download
5 C1B2EM G Tai / Davies Lab Mus musculus / H-2Kb-tsA58 ‘Immortomouse’ metanephros (11.5dpc embryonic kidney) metanephric mesenchyme Jamie Davies download
6 C1B6EM G Tai / Davies Lab Mus musculus / H-2Kb-tsA58 ‘Immortomouse’ metanephros (11.5dpc embryonic kidney) metanephric mesenchyme Jamie Davies download
7 KMMCM G Tai / Davies Lab Mus musculus / H-2Kb-tsA58 ‘Immortomouse’ metanephros (11.5dpc embryonic kidney) metanephric mesenchyme Jamie Davies download
8 KMML1 G Tai / Davies Lab Mus musculus / H-2Kb-tsA58 ‘Immortomouse’ metanephros (11.5dpc embryonic kidney) metanephric mesenchyme Jamie Davies download
9 Six2A3 G Tai / Davies Lab Mus musculus / H-2Kb-tsA58 ‘Immortomouse’ metanephros (11.5dpc embryonic kidney) metanephric mesenchyme Jamie Davies download
10 Six4C6 G Tai / Davies Lab Mus musculus / H-2Kb-tsA58 ‘Immortomouse’ metanephros (11.5dpc embryonic kidney) metanephric mesenchyme Jamie Davies download
11 Six5N5 G Tai / Davies Lab Mus musculus / H-2Kb-tsA58 ‘Immortomouse’ metanephros (11.5dpc embryonic kidney) metanephric mesenchyme Jamie Davies download
12 Six5N6 G Tai / Davies Lab Mus musculus / H-2Kb-tsA58 ‘Immortomouse’ metanephros (11.5dpc embryonic kidney) metanephric mesenchyme Jamie Davies download