Tissue Summaries: developing capillary loop stage nephron (TS22-TS28)

Tissue Summary: developing capillary loop stage nephron (TS22-TS28)

About

developing capillary loop stage nephron Description

The third stage of nephron development is characterized by the presence of microvilli in the proximal tubule, until a clear brush border can be observed and an immature renal corpuscle.
These nephons are located within the outer renal cortex and their anlage of loop of Henle tubular segments have not descended into the medulla.

View development tree
part of	renal cortex
derives from	s-shaped body
differentiates into	maturing nephron & mature nephron

View developing capillary loop stage nephron in GUDMAP Development Tutorials

In Situ Data

Validated Anchor/Marker Genes

Anchors (32)

Anchor genes are defined as genes whose expression is restricted to one temporospatial anatomical compartment. These have been selected by microarray analyses followed by validation using section in-situ hybridisation.

Gene Symbol	Gene MGI ID	Anchor Of	Stage	Also Marker of	GUDMAP ID	Reference
*Acaa1b*	MGI:3605455	renal proximal convoluted tubule (EMAP:29502) segment 2 of proximal tubule (EMAP:29660)	TS28	cortical renal tubule (EMAP:27999) early proximal tubule (EMAP:28005) immature loop of Henle (EMAP:30864)	GUDMAP:9051	Thiagarajan et al. (2011)
*Ace*	MGI:87874	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	TS23		GUDMAP:13511	Thiagarajan et al. (2011)
*Acsm1*	MGI:2152200	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	TS23	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	GUDMAP:10782	Thiagarajan et al. (2011)
*AI317395*	MGI:2143575	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703) renal proximal straight tubule (EMAP:29662)	TS23		GUDMAP:9158	Thiagarajan et al. (2011)
*Aqp11*	MGI:1913583	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	TS23		GUDMAP:13930	Thiagarajan et al. (2011)
*BC089597*	MGI:3583955	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	TS23		GUDMAP:13513	Thiagarajan et al. (2011)
*Bdh2*	MGI:1917022	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	TS23	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	GUDMAP:9152	Thiagarajan et al. (2011)
C2	MGI:88226	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	TS23		GUDMAP:9118	Thiagarajan et al. (2011)
*C230096N06*		capillary loop renal corpuscle (EMAP:27909)	TS23	maturing renal corpuscle (EMAP:27945)	GUDMAP:13516	Thiagarajan et al. (2011)
*Cml1*	MGI:1913366	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703) renal proximal convoluted tubule (EMAP:29502)	TS23		GUDMAP:9133	Thiagarajan et al. (2011)
*Cryl1*	MGI:1915881	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	TS23	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	GUDMAP:11171	Thiagarajan et al. (2011)
*Entpd5*	MGI:1321385	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	TS23		GUDMAP:9175	Thiagarajan et al. (2011)
*Fbp1*	MGI:95492	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	TS23	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	GUDMAP:9177	Thiagarajan et al. (2011)
*Fmo2*	MGI:1916776	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	TS23	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	GUDMAP:9128	Thiagarajan et al. (2011)
*Glyctk*	MGI:2444085	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703) renal proximal straight tubule (EMAP:29662)	TS23		GUDMAP:13504	Thiagarajan et al. (2011)
*Gpd1*	MGI:95679	renal proximal convoluted tubule (EMAP:29502)	TS28	capillary loop renal corpuscle (EMAP:27909) maturing renal corpuscle (EMAP:27945) cortical renal tubule (EMAP:27999) immature loop of Henle (EMAP:30864)	GUDMAP:9049	Thiagarajan et al. (2011)
*Gpsm3*	MGI:2146785	capillary loop renal corpuscle (EMAP:27909)	TS23	maturing renal corpuscle (EMAP:27945)	GUDMAP:13584	Thiagarajan et al. (2011)
*Hdc*	MGI:96062	renal proximal convoluted tubule (EMAP:29502)	TS28	cortical renal tubule (EMAP:27999) early proximal tubule (EMAP:28005) immature loop of Henle (EMAP:30864)	GUDMAP:9163	Thiagarajan et al. (2011)
*Mettl7b*	MGI:1918914	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	TS23	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	GUDMAP:9161	Thiagarajan et al. (2011)
*Mogat2*	MGI:2663253	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	TS23		GUDMAP:13580	Thiagarajan et al. (2011)
*Napsa*	MGI:109365	renal proximal straight tubule (EMAP:29662)	TS28	early proximal tubule (EMAP:28005) immature loop of Henle (EMAP:30864)	GUDMAP:10918 GUDMAP:10919	Thiagarajan et al. (2011)
*Prodh2*	MGI:1929093	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703) renal proximal convoluted tubule (EMAP:29502)	TS23		GUDMAP:9124	Thiagarajan et al. (2011)
*Slc18a1*	MGI:106684	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703) renal proximal convoluted tubule (EMAP:29502)	TS23		GUDMAP:9039	Thiagarajan et al. (2011)
*Slc22a6*	MGI:892001	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703) renal proximal convoluted tubule (EMAP:29502)	TS23		GUDMAP:9116	Thiagarajan et al. (2011)
*Slc23a1*	MGI:1341903	renal proximal straight tubule (EMAP:29662)	TS28	early proximal tubule (EMAP:28005) immature loop of Henle (EMAP:30864)	GUDMAP:10931	Thiagarajan et al. (2011)
*Slc27a2*	MGI:1347099	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	TS23	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	GUDMAP:9179	Thiagarajan et al. (2011)
*Slc3a1*	MGI:1195264	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	TS23	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	GUDMAP:9141	Thiagarajan et al. (2011)
*Slc6a20b*	MGI:1336891	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	TS23	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	GUDMAP:9036	Thiagarajan et al. (2011)
*Sord*	MGI:98266	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	TS23	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	GUDMAP:9136	Thiagarajan et al. (2011)
*Spp2*	MGI:1922646	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703) renal proximal convoluted tubule (EMAP:29502)	TS23		GUDMAP:9147	Thiagarajan et al. (2011)
*Tcn2*	MGI:98534	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	TS23	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	GUDMAP:9178	Thiagarajan et al. (2011)
*Ttr*	MGI:98865	renal proximal straight tubule (EMAP:29662)	TS28	early proximal tubule (EMAP:28005) immature loop of Henle (EMAP:30864)	GUDMAP:11015	Thiagarajan et al. (2011)
*Ugt2b37*	MGI:2148239	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	TS23	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	GUDMAP:9180	Thiagarajan et al. (2011)

Markers (48)

Marker genes are defined as genes which display a regional or enriched expression pattern and may be useful in identifying one or more particular temporospatial compartment(s). These have been selected by microarray analyses followed by validation using section in-situ hybridisation.

Gene Symbol	Gene MGI ID	Marker Of	Stage	Also Marker Of	GUDMAP ID	Reference
*0610005C13Rik*	MGI:1918911	early proximal tubule (EMAP:28005) renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:13955	Thiagarajan et al. (2011)
*2310046K01Rik*	MGI:1916948	early proximal tubule (EMAP:28005)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:10780	Thiagarajan et al. (2011)
*Aadac*	MGI:1915008	early proximal tubule (EMAP:28005) cortical renal tubule (EMAP:27999)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:9034	Thiagarajan et al. (2011)
*Acaa1b*	MGI:3605455	early proximal tubule (EMAP:28005) cortical renal tubule (EMAP:27999)	TS23	renal proximal convoluted tubule (EMAP:29502) segment 2 of proximal tubule (EMAP:29660) immature loop of Henle (EMAP:30864)	GUDMAP:9040	Thiagarajan et al. (2011)
*Acsm1*	MGI:2152200	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	TS28	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	GUDMAP:10934	Thiagarajan et al. (2011)
*Aldh1l1*	MGI:1340024	early proximal tubule (EMAP:28005) early distal tubule (EMAP:28009)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:13954	Thiagarajan et al. (2011)
*Ambp*	MGI:88002	early proximal tubule (EMAP:28005)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:13579	Thiagarajan et al. (2011)
*Apom*	MGI:1930124	early proximal tubule (EMAP:28005) cortical renal tubule (EMAP:27999) renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	TS23		GUDMAP:10784	Thiagarajan et al. (2011)
*Bdh2*	MGI:1917022	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	TS28	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	GUDMAP:9151	Thiagarajan et al. (2011)
*Cgref1*	MGI:1915817	early proximal tubule (EMAP:28005) cortical renal tubule (EMAP:27999) renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:9173	Thiagarajan et al. (2011)
*Cideb*	MGI:1270844	early proximal tubule (EMAP:28005) cortical renal tubule (EMAP:27999)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:9166	Thiagarajan et al. (2011)
*Clic6*	MGI:2146607	early proximal tubule (EMAP:28005)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:9149	Thiagarajan et al. (2011)
*Cryl1*	MGI:1915881	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	TS28	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	GUDMAP:11170	Thiagarajan et al. (2011)
*Dpep1*	MGI:94917	early proximal tubule (EMAP:28005)	TS23	maturing renal corpuscle (EMAP:27945)	GUDMAP:9126	Thiagarajan et al. (2011)
*Eral1*	MGI:1889295	capillary loop renal corpuscle (EMAP:27909)	TS23	maturing renal corpuscle (EMAP:27945)	GUDMAP:13585	Thiagarajan et al. (2011)
*Fbp1*	MGI:95492	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	TS28	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	GUDMAP:9181	Thiagarajan et al. (2011)
*Fbp2*	MGI:95491	early proximal tubule (EMAP:28005)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:13581	Thiagarajan et al. (2011)
*Fmo2*	MGI:1916776	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	TS28	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	GUDMAP:13941	Thiagarajan et al. (2011)
*Gpd1*	MGI:95679	cortical renal tubule (EMAP:27999) capillary loop renal corpuscle (EMAP:27909)	TS23	maturing renal corpuscle (EMAP:27945) renal proximal convoluted tubule (EMAP:29502) immature loop of Henle (EMAP:30864)	GUDMAP:9047	Thiagarajan et al. (2011)
*Gyk*	MGI:106594	early proximal tubule (EMAP:28005) early distal tubule (EMAP:28009) renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:9155	Thiagarajan et al. (2011)
*Hdc*	MGI:96062	early proximal tubule (EMAP:28005) cortical renal tubule (EMAP:27999)	TS23	renal proximal convoluted tubule (EMAP:29502) immature loop of Henle (EMAP:30864)	GUDMAP:9164	Thiagarajan et al. (2011)
*Kcnj1*	MGI:1927248	early distal tubule (EMAP:28009)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:20762	Thiagarajan et al. (2011)
*Mettl7b*	MGI:1918914	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	TS28	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	GUDMAP:9160	Thiagarajan et al. (2011)
*Myo15b*	MGI:2685534	early proximal tubule (EMAP:28005) cortical renal tubule (EMAP:27999)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:9038	Thiagarajan et al. (2011)
*Napsa*	MGI:109365	early proximal tubule (EMAP:28005)	TS23	renal proximal straight tubule (EMAP:29662) immature loop of Henle (EMAP:30864)	GUDMAP:10917	Thiagarajan et al. (2011)
*Pipox*	MGI:1197006	early proximal tubule (EMAP:28005) cortical renal tubule (EMAP:27999)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:10786	Thiagarajan et al. (2011)
*Pter*	MGI:107372	early proximal tubule (EMAP:28005) renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:8210	Thiagarajan et al. (2011)
*Scnn1b*	MGI:104696	early distal tubule (EMAP:28009)	TS23	collecting duct (EMAP:8233)	GUDMAP:11303	Thiagarajan et al. (2011)
*Serpina10*	MGI:2667725	early proximal tubule (EMAP:28005)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:9131	Thiagarajan et al. (2011)
*Sigirr*	MGI:1344402	early proximal tubule (EMAP:28005) early distal tubule (EMAP:28009)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:10776	Thiagarajan et al. (2011)
*Slc23a1*	MGI:1341903	early proximal tubule (EMAP:28005)	TS23	renal proximal straight tubule (EMAP:29662) immature loop of Henle (EMAP:30864)	GUDMAP:9176	Thiagarajan et al. (2011)
*Slc27a2*	MGI:1347099	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	TS28	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	GUDMAP:9182	Thiagarajan et al. (2011)
*Slc3a1*	MGI:1195264	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	TS28	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)		Thiagarajan et al. (2011)
*Slc6a13*	MGI:95629	early proximal tubule (EMAP:28005) cortical renal tubule (EMAP:27999)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:9168	Thiagarajan et al. (2011)
*Slc6a20b*	MGI:1336891	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	TS28	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	GUDMAP:10929	Thiagarajan et al. (2011)
*Sord*	MGI:98266	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	TS28	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	GUDMAP:9135	Thiagarajan et al. (2011)
*Sox9*	MGI:98371	cortical renal tubule (EMAP:27999)	TS23	ureteric tip (EMAP:27752) renal vesicle (EMAP:27831) s-shaped body (EMAP:27855)	GUDMAP:20765	Thiagarajan et al. (2011)
*Stc2*	MGI:1316731	capillary loop renal corpuscle (EMAP:27909)	TS23	s-shaped body (EMAP:27855) maturing renal corpuscle (EMAP:27945)	GUDMAP:13703	Thiagarajan et al. (2011)
*Susd2*	MGI:1918983	cortical renal tubule (EMAP:27999) capillary loop renal corpuscle (EMAP:27909)	TS23	maturing renal corpuscle (EMAP:27945) immature loop of Henle (EMAP:30864)	GUDMAP:9170	Thiagarajan et al. (2011)
*Susd3*	MGI:1913579	early proximal tubule (EMAP:28005) cortical renal tubule (EMAP:27999)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:13582	Thiagarajan et al. (2011)
*Tcn2*	MGI:98534	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	TS28	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	GUDMAP:10922	Thiagarajan et al. (2011)
*Tesc*	MGI:1930803	cortical renal tubule (EMAP:27999)	TS23	collecting duct (EMAP:8233)	GUDMAP:11297	Thiagarajan et al. (2011)
*Tmem72*	MGI:2442707	early distal tubule (EMAP:28009)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:20769	Thiagarajan et al. (2011)
*Ttc36*	MGI:2384760	early proximal tubule (EMAP:28005) cortical renal tubule (EMAP:27999)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:13583 GUDMAP:13704	Thiagarajan et al. (2011)
*Ttr*	MGI:98865	early proximal tubule (EMAP:28005)	TS23	renal proximal straight tubule (EMAP:29662) immature loop of Henle (EMAP:30864)	GUDMAP:11016	Thiagarajan et al. (2011)
*Ugt2b37*	MGI:2148239	renal proximal convoluted tubule (EMAP:29502) renal proximal straight tubule (EMAP:29662)	TS28	early proximal tubule (EMAP:28005) early proximal tubule of maturing nephron (EMAP:31703)	GUDMAP:9183	Thiagarajan et al. (2011)
*Umod*	MGI:102674	renal proximal convoluted tubule (EMAP:29502) distal convoluted tubule (EMAP:29508) distal straight tubule (EMAP:29505)	TS28	loop of Henle, inner medullary portion (EMAP:29583) thin ascending limb (EMAP:29585) loop of Henle (EMAP:29666) distal straight tubule (EMAP:29672) loop of Henle (EMAP:29680) premacula segment of distal straight tubule (EMAP:29684) immature loop of Henle (EMAP:30864)	GUDMAP:10911:GUDMAP:10912	Thiagarajan et al. (2011)
*Unc5cl*	MGI:1923839	early proximal tubule (EMAP:28005) cortical renal tubule (EMAP:27999)	TS23	immature loop of Henle (EMAP:30864)	GUDMAP:13938	Thiagarajan et al. (2011)
*Vdr*	MGI:103076	early proximal tubule (EMAP:28005)	TS23		GUDMAP:13935	Thiagarajan et al. (2011)

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