GUDMAP 2 Projects
Project descriptions for GUDMAP 1
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PIs: Richard Baldock & Jamie Davies
project details to follow ...
project details to follow ...
The primary functions of the mature lower urinary tract – storage and voiding – depend on a healthy central and peripheral nervous system. In the immature postnatal system, voiding is “automatic”, i.e., controlled by spinal and local processes. However, during further maturation there is a dramatic transition in regulatory mechanisms, such that in the healthy adult, filling triggers a conscious need to void but micturition is determined voluntarily by the brain to occur at an appropriate time and place. Around puberty, further changes coordinate bladder, bowel and sexual activity. Numerous changes occur in the nervous system over these periods, although the cellular loci and molecular mechanisms have not been well defined... more
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The urinary outflow tract, including the renal pelvis, ureters, bladder and upper urethra, is lined by a specialized stratified epithelium called the urothelium, composed of a basal layer, an intermediate layer and a superficial layer consisting of umbrella cells. Umbrella cells are large multinucleated cells that are specialized for synthesis and trafficking of Uroplakins, a family of secreted proteins that assemble into the crystallin plaque lining the apical surface of the urothelium that generates a leak-proof barrier between the urine and the blood… more
