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RFA Now Open: Collaborative Computational Tools for a Human Cell Atlas

For program and registration details, please go here: Full Details here


The 2017 Columbia O'Brian Urology Center Symposium, March 31 2017

"The Genomics & Genetics of Urogenital & Other Organ Malformations"

For program and registration details, please go here: http://cumcobriencenter.com/columbia-george-m-obrien-center-events/symposium/


Announcing 2017 Funding Opportunities for the Diabetic Complications Consortium (DiaComp)

Thank you for your interest in the funding program activities of DiaComp.  We have updated the areas of interest for the 2017 Pilot & Feasibility program solicitation.  In addition, the Collaborative Funding Program solicitation will support planning activities for the development of a multi-center study for clinical biomarkers and outcome measures for diabetic foot ulcers.  Please follow the links below to find out more information about these exciting funding opportunities.

Click the links below to find out more information!

For complete details about this program, go to:
2017 DiaComp Pilot & Feasibility Program
2017 Conference Support Program
2017 Collaborative Funding Program



The 2017 DiaComp Pilot & Feasibility Program

The NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is soliciting applications for its annual Pilot and Feasibility Program

Applications of 5 pages requesting up to $100,000 for one year are due June 12, 2017.

Current areas of interest include, but are not limited to:

Who is eligible to apply?
Applications are accepted from both National and International institutions/ organizations.

What funds are available for P&F Projects?
Applicants may request up to $100,000 (direct + indirect costs) Total Costs for one year. The number of awards will depend upon the number, quality, duration, and cost of the applications received. Awards will be made as subcontracts from the DiaComp Coordinating Unit (CU) at Augusta University and NOT directly by the NIH.

Timetable for P&F Application Submissions.
June 12th Deadline for applications submitted to the DiaComp CU.
Oct. 1st Estimated Start Date for DiaComp P&F Project funding.

Contact Information
For more detailed information, please go to http://www.diacomp.org/shared/pilotFeasibility.aspx


The 2017 DiaComp Conference Support Program

The NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is soliciting applications for the Conference Support Program

Applications of 5 pages requesting up to $20,000 per conference are due June 12, 2017 for conferences with start dates after September 1, 2017.
A scientific conference is defined as a symposium, seminar, workshop, or formal conference where individuals assemble to exchange scientific information.
This program supports high-quality scientific conferences that feature sessions or speakers directly relevant to diabetic complications and that promote communication and collaboration between research communities investigating similar pathologic mechanisms in different end organs of complications. Strong proposals will also inform investigative communities that have not traditionally been involved in complications research.

A few examples of meritorious proposals might include, but are not limited to:

Who is eligible to apply?
Domestic institutions or organizations, including established scientific or professional societies, are eligible to apply for conference support. Foreign institutions are NOT eligible to apply for conference support. Both domestic and international conferences may be supported; however, an international conference can be supported only through the U.S. representative organization of an established international scientific or professional society. Requests for conferences held outside of North America are generally not allowed. An individual is not eligible to receive a grant in support of a conference.

What funds are available for Conference Support Projects?
Applicants may request up to $20,000 per conference per year. Multi-year applications are NOT allowed. The number of awards will depend upon the number, quality, and cost of the applications received. Facilities and Administrative (F&A) costs are NOT allowed. Awards will be made as subcontracts from the DiaComp Coordinating Unit (CU) at Augusta University and NOT directly by the NIH.

Timetable for P&F Application Submissions.
June 12th Deadline for applications submitted to the DiaComp CU.
Sept. 1st Minimum conference start dates

Contact Information
For more detailed information, please go to http://www.diacomp.org/shared/conferenceSupport.aspx


2017 Collaborative Funding Program

The NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is soliciting applications for the Collaborative Funding Program

Applications of 6 pages requesting up to $100,000 for one year are due March 10, 2017

Summary:
Diabetic foot ulcers are the most common cause of non-traumatic lower leg amputation in the United States. Despite efforts to prevent and treat foot ulcers, each year about 70,000 Americans with diabetes will lose part of their lower extremity because a foot ulcer becomes infected or does not heal. An obstacle to the development of therapies is the paucity of validated biomarkers that assess healing, infection, and recurrence risk, and validated outcomes that measure patient satisfaction and quality of life. In addition, systematic reviews of clinical studies on the prevention and management of diabetic foot ulcers consistently point to the urgent need for clinical trials with standardized definitions, outcomes, biomarkers, and protocols that will enable a thorough evaluation of treatments and comparison of results across trials.

The purpose of this program is to support planning activities for the development of a multi-center study for clinical biomarkers and outcome measures for diabetic foot ulcers. It is also part of an effort by the NIDDK to support clinical studies that involve two or more institutions to build a collaborative framework for ongoing research on diabetic wound healing.

Applications should propose a future clinical study based on the criteria listed below. The application should include a rationale for the future clinical study, documenting significance and need, and describe the potential impact of the clinical study on biomarkers and research infrastructure. Preliminary results and background to support the study and an overview of the study design should be provided. The latter should include an estimate of the number of subjects, entry criteria, and outcome measures. In addition, the application should describe the planning activities proposed to be conducted during the single year of this program. These may include meetings to develop the protocol, focus groups for the patient-centered outcomes, clinical studies to obtain preliminary data, quality control testing of patient sample analysis, biostatistical analysis to develop sample size calculations, or analysis of databases to inform recruitment strategies. The goal of the planning activities is to develop a complete study protocol for the validation of a biomarker or outcome measure for diabetic foot ulcers.

Who is eligible to apply?
Applications are accepted from both National and International institutions/ organizations.

What funds are available?
Applicants may request up to $100,000 (direct + indirect costs) Total Costs for one year. The number of awards will depend upon the number, quality, duration, and cost of the applications received. Awards will be made as subcontracts from the DiaComp Coordinating Unit (CU) at Augusta University and NOT directly by the NIH.

Timetable for P&F Application Submissions.
March 10th Deadline for applications submitted to the DiaComp CU.
May 31st Estimated Start Date for Planning Activities funding

Contact Information
For more detailed information, please go to http://www.diacomp.org/collaborative.aspx

Address questions regarding the DiaComp Funding Programs:
Richard A. McIndoe, Ph.D. (Director)
DiaComp Coordinating Unit
Augusta University
Phone: 706-721-3542
Fax: 706-721-3688
Email: rmcindoe@augusta.edu


Calls for ReBuilding a Kidney Partnership Projects

The (Re)Building A Kidney Consortium is happy to announce that we are accepting a new round of submissions to collaborate with us via our Partnership Program. We are looking for additional projects in the following subject areas:

1. Development of protocols for single cell analysis of human renal biopsy specimens. Protocols may involve tissue in situ analyses or digestion of specimens into single cells for transcriptional or proteomic analysis.

2. Profiling and validation of normal adult kidney cell types isolated from human tissue using FACS, laser-capture or other approaches. Omic profiling of kidney cell types will inform in vitro and in vivo efforts to recreate or regenerate these cell types within the RBK Consortium and provide the research community with detailed expression profiles of specific kidney cell types.

3. Development of protocols for proteomic profiling of kidney cell types using platforms amenable to single cell analysis (flow cytometry, microfluidics, mass cytometry or chemical cytometry) and/or the development of proteomic imaging methods at the single cell level (e.g., SWITCH, systems-wide control of interaction time and kinetics of chemicals, CyTOF mass cytometry, etc.)

4. Bioengineering specific components of the kidney (e.g., convoluted proximal tubule, collecting duct, interstitium, etc.), including incorporation of appropriate cell types. Cell types may be informed by the RBK Consortium.

Applications of 5 pages requesting up to $150,000 total costs for per year for a maximum of 2 years are due July 1, 2016 for a projected start date of October 3, 2016.

For complete details about this program, go to: https://www.rebuildingakidney.org/partnership-project-program.html


GUDMAP Workshop - International Workshop on Developmental Nephrology (IWDN), 12-16th July 2015

The 13th International Workshop on Developmental Nephrology (IWDN) will be held in Snowbird, Utah, 12-16th July 2015. GUDMAP will be hosting a Workshop on 13th July, 2015. For program and further information, please go here: http://iwdn.ipna-online.org


GUDMAP Workshop - Nephrotools International Conference, 8-10th September 2015

The next Nephrotools International Conference, called "The Kidney: Development, Disease and Regeneration” will be held at the University of Liverpool, UK, 8th-10th September 2015. GUDMAP will be hosting a half-day Workshop on 8th September, 2015. For information on program and registration details please go here: http://www.kidneyconference.com/


GUDMAP Node posting - Report from ISN World Congress in Cape Town (March 13-17, 2015)

The International Society of Nephrology (ISN) holds biennial meetings throughout the world, and this was the first ISN WCN to be held in Africa. There was attention brought by the scientific program to maternal and child renal health, both of which are key problems in the developing world. There was additional emphasis on translational and clinical nephrology, with the session entitled ‘Congenital anomalies of the kidney and urinary tract: Prenatal through adulthood’ being of particular relevance to developmental biologists... more.

Dr. Chris Armit attended the ISN World Congress in Cape Town and represented GUDMAP at an exhibiton stand. His full report can be read at the Node.


NIDDK Funding Calls

RFA-RM-15-002: Exploratory Technologies to Understand the Control of Organ Function by the Peripheral Nervous System for SPARC (U18)

The NIH Common Fund Program on Stimulating Peripheral Activity to Relieve Conditions (SPARC) has released its first request for applications, RFA-RM-15-002: Exploratory Technologies to Understand the Control of Organ Function by the Peripheral Nervous System for SPARC (U18). This RFA solicits applications to develop new and/or enhance existing tools and technologies tailored to elucidate the neurobiology and neurophysiology underlying autonomic control of internal organs in health or disease, to inform next generation neuromodulation therapies.

SPARC is uniquely positioned to serve as a community resource that provides the broader public and private research communities with the scientific foundation necessary to create more effective and minimally invasive neuromodulation therapies. The program has the central goal of providing a basic understanding of the peripheral nervous system to catalyze development of new or more efficacious therapies based on neuromodulation of end-organ system function. This first step will support exploratory studies to develop a broad range of technologies, spanning sensing to stimulation to surgical techniques to model systems. The 2 year awards resulting from this FOA will establish feasibility for further technology development and lay the groundwork to more systematically facilitate biological mapping activities in future SPARC initiatives.

Detailed in the FOA, the cooperative agreement mechanism will involve active participation in SPARC program events and NIH partnership in supporting and stimulating the recipients’ activities.

Due Dates: Letter of Intent – March 14, 2015, Application – April 14, 2015

Please contact SPARC_NextGen-Tools@mail.nih.gov if you have any questions regarding this funding opportunity. In addition, please feel free to share this announcement with your colleagues.


Sequencing Data

GUDMAP has recently had 6 Next-Gen Sequencing Series added to its database. Data comes from Steve Potter (including kidney single cell data), Cathy Mendelsohn (developing lower urinary region), Sanjay Jain (dorsal root ganglion). These are accessible here: GUDMAP Sequencing Series.


Euregene

The EuReGene Project website has now been moved so that it is housed within GUDMAP. This is to ensure it's continued existence and availavility. The new URL to access EuReGene is www.gudmap.org/euregene

The existing Xenopus data (XGEbase) is being ported to the XenBase project (http://www.xenbase.org). This will become the primary route for accessing this data (although it will remain available in an unsupported format through EuReGene).

All EuReGene (mouse) data is now fully incorporated into the GUDMAP database - available through it's browse and search tools.
IMPORTANT NOTE ABOUT EUREGENE ANNOTATIONS: Annotations within EuReGene entries are currently under review by the GUDMAP editorial office and Kylie Georgas (Little Lab, University of Queensland). In due course the annotations will be changed to reflect this review process. Original EuReGene annotations will continue to be available from www.gudmap.org/euregene


GUDMAP Reporter Strain Nominations

GUDMAP is generating new mouse strains for analysis of developing urogenital system. Go to our Reporter Strain Nominations page to nominate genes.


Upcoming Events

Follow the above link to view upcoming events and conference of general interest to researchers, clinicians and bioinformaticians in the field of genitourinary disease & development.


GUDMAP Publications

Harding SD, Armit C, Armstrong J, Brennan J, Cheng Y, Haggarty B, Houghton D, Lloyd-MacGilp S, Pi X, Roochun Y, Sharghi M, Tindal C, McMahon AP, Gottesman B, Little MH, Georgas K, Aronow BJ, Potter SS, Brunskill EW, Southard-Smith EM, Mendelsohn C, Baldock RA, Davies JA, Davidson D. The GUDMAP database – an online resource for genitourinary research. Development. 2011 Jul; 138(13):2845-2853.

Georgas KM, Chiu HS, Lesieur E, Rumballe BA, Little MH. Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules.
Dev Dyn. 2011 Aug;240(8):spcone. doi: 10.1002/dvdy.22697.

Abler LL, Mehta V, Keil KP, Joshi PS, Flucus CL, Hardin HA, Schmitz CT, Vezina CM. A High Throughput in situ Hybridization Method to Characterize mRNA Expression Patterns in the Fetal Mouse Lower Urogenital Tract.
J Vis Exp. 2011 Aug 19;(54). pii: 2912. doi: 10.3791/2912.

Hendry C, Rumballe B, Moritz K, Little MH. Defining and redefining the nephron progenitor population.
Pediatr Nephrol. 2011 Sep;26(9):1395-406. Epub 2011 Jan 14.

Mehta V, Abler LL, Keil KP, Schmitz CT, Joshi PS, Vezina CM. Atlas of Wnt and R-spondin gene expression in the developing male mouse lower urogenital tract.
Dev Dyn. 2011 Sep 20. doi: 10.1002/dvdy.22741.[Epub ahead of print]

Abler LL, Keil KP, Mehta V, Joshi PS, Schmitz CT, Vezina CM. A high-resolution molecular atlas of the fetal mouse lower urogenital tract.
Dev Dyn. 2011 Oct;240(10):2364-77. doi: 10.1002/dvdy.22730. Epub 2011 Sep 8.



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